Investissements récents : Manus et la découverte de médicaments

Retrouvez l'épisode en version française ici : https://www.gdiy.fr/podcast/reid-hoffman-vf/

“There is no if. There is only when.”

That’s how Reid Hoffman answers when asked whether AI will revolutionize business, help govern nations, or cure cancer.

And he’s earned the right to say it. In the six months between his first appearance on GDIY and this one, we’ve witnessed some of the biggest breakthroughs in AI history.

But those same six months have also deepened the rift between the U.S. and Europe.

While most of Silicon Valley’s leaders are bowing to President Trump’s politics of fear, Reid remains one of the few willing to challenge it — defending freedom of speech in its purest form, not the version sanctioned by power.

After co-founding PayPal and LinkedIn, he went on to serve on the boards of dozens of companies including OpenAI until 2023, and Microsoft, where he still sits today.

He also advises several governments seeking to understand how AI can be deployed responsibly across society — and even in governance itself.

In this episode, Reid shares how to unlock AI’s full potential, and how he personally uses it every day : to write, to think, and to challenge his own ideas.

A brilliant, grounded mind — far from the radical “tech bros” — driven not by hype, but by a genuine belief in progress.

TIMELINE:

• 00:00:00 : “AI is a fantastic enablement of human connection”
• 00:13:00 : Reid's best hacks for daily uses of AI
• 00:23:08 : How to help governments deploy AI in society
• 00:34:19 : What Trump’s fear-based government is changing in the US
• 00:52:43 : The vibe-coding revolution and why you should pay attention
• 01:04:48 : Curing cancers with AI?
• 01:09:50 : Why everybody should use AI, even retired people
• 01:16:18 : Start a company with $0 in 2025: what would Reid do
• 01:23:09 : Amazon, Microsoft, Google: who’s winning the AI race
• 01:31:12 : “Don’t be anxious. Be aware and keep pushing.”

We referred to previous GDIY episodes :

• #452 - VO - Reid Hoffman - LinkedIn, Paypal - L’humanité 2.0 : Homo technicus plus qu’Homo sapiens
• #452 - VF - Reid Hoffman - LinkedIn, Paypal - “We are more Homo technicus than Homo sapiens”
• #487 - VF - Anton Osika - Lovable - Internet, Business et IA : rien ne sera jamais plus comme avant
• #487 - VO - Anton Osika - Lovable - Internet, Business, and AI: Nothing Will Ever Be the Same Again
• #426 - Thomas Clozel - Owkin - Comment casser Big Pharma grâce à l’IA
• #473 - VO - Brian Chesky - Airbnb - « We're just getting started »
• #473 - VF - Brian Chesky - Airbnb - « Après 17 ans, nous ne sommes qu’au début de notre histoire »

A few recent episodes in English :

• #437 - James Dyson - Dyson - “Failure is more exciting than success”
• #431 - Sean Rad - Tinder - How the swipe fever took over the world
• #475 - VO - Shane Parrish - Farnam Street - Clear Thinking: The Decision-Making Expert

We spoke about :

• Possible Podcast - Reid Hoffman
• Eleven Labs
• 7 magic products of Google
• Manas AI
• The Lafayette Fellowship
• Squarespace
• OpenAI Jobs Platform

Reading Recommendations :

• Superagency - Reid Hoffman
• The Emperor of All Maladies - Siddhartha Mukherjee
• A Brief History of Intelligence - Max Bennett
• The Road Less Traveled - Scott Peck

Check out Reid’s YouTube channel and his podcast Possible.

You can also follow Reid on LinkedIn (of course) and on Instagram.

Interested in sponsoring Generation Do It Yourself or proposing a partnership ? Contact my label Orso Media through this form.

Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.