Intro

Alzheimer’s is not inevitable—and it may even be optional. In this groundbreaking episode, you’ll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer’s researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer’s is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. 

Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You’ll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. 

This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You’ll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. 

You’ll Learn: 

• Why Alzheimer’s can begin as early as your 20s and what biomarkers to track 

• The seven major drivers of Alzheimer’s and how to reverse them with biohacking strategies 

• How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it 

• The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity 

• Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s 

• How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Keywords: Alzheimer’s prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer’s, Paraquat Parkinson’s risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer’s, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine 

Thank you to our sponsors!  

• EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  
• OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. 

Resources:  

• Dale’s Website: https://www.apollohealthco.com/dr-bredesen/ 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

0:00 — Trailer 

1:10 — Introduction  

2:43 — Personal Story 

7:52 — APOE4, Genetics, and Drug Development 

11:37 — Pharma, Media, and Pushback 

17:13 — Prevention, Stages, and Biomarkers 

23:34 — Causes and Mechanisms 

30:24 — Parkinson’s, Toxins, and Mitochondria 

37:17 — Longevity, Biohacking, and Protocols 

44:11 — AI, Data, and Future Treatments 

54:11 — Case Studies and Success Stories 

1:03:00 — Detox, Mold, and Environmental Triggers 

1:12:00 — Neuroplasticity and Brain Regeneration 

1:20:00 — Hormones, Supplements, and Personalized Hacks 

1:29:00 — Cortisol, Addison’s, and AI Protocols 

1:38:00 — Large-Scale Trials and Global Impact 

1:45:00 — Final Takeaways 

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