TWiV 1231: What is a virus?
This Week in Virology
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Unraveling Viral Glycoproteins in Vaccine Development
This chapter explores the critical role of viral glycoproteins in virus attachment and neutralization, emphasizing the need for stabilizing these proteins in their pre-fusion state to enhance vaccine efficacy. It discusses the complexities of monoclonal antibody development and the impact of specific amino acid changes on the rabies virus's ability to enter host cells. Additionally, the chapter examines antibody resistance mutations and the implications of various experimental approaches for improving rabies virus vaccines.
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