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David Baker | De Novo Protein Design

Foresight Institute Radio

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Nanocages for Cancer Therapy - A New Design Nanomaterial

We can actually use these kind of devices I described earlier to do calculations on the surface of cells. So one of the challenges in cancer therapy is, could you have little machines that go in and kill the tumor cells, but leave normal cells fine, untouched? And that's a hard problem because cancer cells don't often differ very much from normal cells. We've been doing with this is attaching binding domains for cell surface receptors and we get the cells to undergo all sorts of interesting transitions. One idea is self-assembling, circuit-real. A lot of manufacturing is top-down. And here we can proceed bottom-up.

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