A lean mass hyper-responder is someone with high LDL and HDL cholesterol and low triglycerides. They are often lean and healthy people who present with strange and alarming lipid numbers after going on the ketogenic diet. Dave Feldman, Dr. Nick Norwitz & Dr. Dominic D’Agostino discuss the LMHR phenotype, whether it’s a concern, whether it’s rare, the Oreo vs statin study, how exercise levels might play a role, and why more research is needed.

Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠https://levels.link/wnl⁠⁠⁠

Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.

🎙 What Dave Feldman, Nick Norwitz, PhD, & Dominic D’Agostino, PhD, discuss:

(4:29) — What is the lean mass hyper-responder phenotype?

(8:32) — Often the LMHR phenotype gets noticed when someone goes low carb

(19:02) — The Oreo cookie study garnered attention for the LMHR phenotype

(25:32) — Understanding the mechanisms of the LMHR

(40:04) — Exercise levels likely play a role in LMHR

(51:26) — The alarming LDL levels in LMHR prompted research

(59:25) — The “gym hypothesis” will be important for further research

(1:10:48) — An open and respectful dialogue is needed on the topic

(1:33:47) — The importance of additional research

⁠⁠Transcripts & Show notes⁠⁠⁠

🔗 Helpful links:

Watch the conversation: ⁠https://youtu.be/ItNGrGNvESY

Episode #388 - Don't Worry Darling

The Flop House

Is There a Twist in the Lighthouse?

The AI-powered Podcast Player