This chapter examines the effects of substances like Adderall and psychedelics on cognition and self-perception, contrasting past and current trends in substance use among college students. It also addresses pressing issues surrounding mental health, gender identity, and societal pressures, critiquing media portrayals and the implications of contemporary cosmetic practices. The conversation raises important questions about the risks associated with drug use and medical interventions, ultimately advocating for a more understanding and humane approach to mental health.