Fatty Acids, ROS, and Insulin Resistance

• The major issues with the ROS theory of obesity

• Why fat-burning is inefficient and doesn’t lead to healthy fat loss

• The real problem with PUFA (and why they don’t decrease ROS production)

• Why carbohydrates and insulin don’t cause fat gain

• How increasing cellular energy through efficient mitochondrial respiration is the key to healthy fat loss

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-47-a-critique-of-the-ros-theory-of-obesity-the-croissant-diet-part-1/

Timestamps:

3:26 – an introduction to The Croissant Diet and Fire In A Bottle

10:04 – an introduction to ROS and the varying ROS-producing effects of fats and carbs

16:10 – the ROS theory of obesity, Randle cycle confusion, and how fat-burning causes physiological insulin resistance

25:30 – the effect of fatty acid saturation on ROS production when oxidized in mitochondria

29:36 – the real problem with PUFA and why they lead to increases in ROS production rather than decreases

42:28 – why the inefficient mitochondrial respiration that’s fueled by fatty acid oxidation and produces excessive amounts of ROS harms our health

47:39 – the problems with the idea of hormesis

58:39 – why fat-burning doesn’t increase fat loss

1:05:45 – anti-hormesis and the bioenergetic view of obesity