The Immunology Podcast cover image

Ep. 49: “Viruses and Aging” Featuring Dr. Clovis Palmer

The Immunology Podcast

00:00

Cars for Leukemia

The standard car that has been kind of done since 30 years, basically consists on a antibody binding. And they're great for certain leukemias nowadays, not as a treatment,. But there's a lot of often kind of tonic signaling that negatively affects their longevity or their results in unwanted activation. This is a very problematic when you want to go move away from CD19 specific cars to other targets and things like that. They started looking at other components of the TCR signaling pathway and the TCR signalling complex; how would they have any potential as a signaling domain for a car. One of the molecules that really catches their attention is ZAP 17 which is one of the, it

Transcript
Play full episode

The AI-powered Podcast Player

Save insights by tapping your headphones, chat with episodes, discover the best highlights - and more!
App store bannerPlay store banner
Get the app