DDX-41 Mutated Myeloid Neoplasms - A Unique Subtype of Myelodysplastic Diseases

The authors conclude that DDX-41 mutated MDS defines a unique subtype of myeloid neoplasms. TP-53 mutations did not adversely affect patient outcomes, and their poor prognostic effect was completely mitigated by the presence of DDx-41 mutations. The lifelong risk of developing myeloidNeoplasms from a pathogenic or likely pathogenic germlineDDX-41 variant is approximately 50%.