Is There a Free Lunch?

When you when you work bottom up, in other words, when you're really trying to, my micro manage the situation, it's on you to get all the details right. There's lots of opportunity for side effects. A too much signalling, not enough signalling, allthat cind o stap. The benefit of going top down signals is that you are not providing the details. You're providing a very low information cont input that says, build an eye here. And we've done that. For example, we figured out how to make other tissues in the embryo, including the gut, to make a perfectly good eye. When you do that, we don't provide all the information