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PROTACs Roundtable: Bertozzi and Deshaies

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Protas and Moleculegles

Yoo, dark harolin rags, thank you so much for a taking the time to talk to me to day. And you gong to talk about proximity inducing drugs to day, eh? So maybe we can talk about protas first, and maybe then talk a bit more about moleculegles. So re can you explain to us what a prote is and what it does? The idea is that both hands are grasping at the same so you make a ternary complex that contains your target and the ubiquit ligas ensie bridged by the protact molecule.

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