Caffeine is an example of how we become tolerant to the effects of a particular substance. If I'm having lots more caffeine, it's also having impact on my digestive system and adrenals. So there are all these other effects that could get arrayed just because I need an ever increasing dose of the same substances. That crude analogy is kind of like what's happening in insulin with insulin and blood sugar. We're going to talk about the main underlying mechanisms for insulin resistance. The main mechanisms are glute for insulin signaling, fat in the liver and muscle, and inflammation which invariably leads to mitochondrial dysfunction.
In today’s solo episode and I’ll be talking about insulin resistance, how this impacts your risk of disease and why insulin resistance could drive many chronic conditions and why certain lifestyle measures work for improving metabolic health.
By the end of the episode you will understand:
The relationship between IR and disease
The importance of sugar balance in the body
What insulin is and how insulin works
What happens when we become resistant to insulin
What are the causes of IR
What we can do to become more insulin sensitive and ultimately prevent disease
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