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16min chapter
04 - Drew Weissman, MD, PhD - Giants of Gene Therapy
ASGCT Podcast Network
Early Trials and Triumphs of mRNA Technology
This chapter explores the early investigations into mRNA's inflammatory responses, detailing significant discoveries from 1998 and the challenges faced in the research community. It recounts a turning point in 2017 that led to the successful development of mRNA vaccines, emphasizing the importance of nucleoside modification and lipid nanoparticles. Additionally, the chapter reflects on the rapid progression of vaccine development during the COVID-19 pandemic and the ongoing struggle against vaccine misinformation.
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