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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
Huberman Lab
The NMDA Receptor and Neuroplasticity
The NMDA receptor controls neural activity in the immediate sense. But it also can engage gene expression and introduce new receptors to the cell, giving the cell the ability to then recreate the same patterns of activity without having to do it in such a metabolically demanding way. In fact, a good analogy for all of this is the way that muscles can hypertrophy, right? If you overload muscles properly through resistance, training of any kind, and then give them a period of rest, there's recruitment of specific things to the muscle fibers. And then those muscles grow, they get stronger, etc. They don't have to damage those muscle fibers or trigger those adaptations over and over again to maintain
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