3min chapter

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#212 - The neuroscience of obesity | Stephan Guyenet, Ph.D.

The Peter Attia Drive

CHAPTER

The Heritability of Obesity

It seems like the only thing we know is it's not too low an amount of circulating lepton, as evidenced by two things. There were some early studies done in animal models suggesting that if you mash up the hypothalmus and you look at what's going on in it,. On average, on average, find that the amount of leptin response, the inter cellular signaling cascade that's activated by lepton, is not really impaired in animals with obesity. It's like their getting the same lepton signal from a much higher level of lepton. So clearly, our susceptibility for obesity has been with us for a great period of time, and it is highly high preserved. We now have matched

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