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Show Notes:

Early and late long-term effects of vasectomy on serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels

Questions:

30 Day Reset - Loss of Appetite

Julie writes:

Some personal info:

I'm a 40 year old female. 5'3." BMR is 1,542 (based on a calculator I found using the google machine). 199 pounds.

On September 1, I started the 30 Day Reset. During July and August, I was more conscious about what I was eating and lost 18 pounds. While doing that, I read Wired to Eat and decided to use September for the 30 Day Reset. Today is September 4, so this is just my 4th day on the reset.

Yesterday morning I woke up hungry (which is abnormal for me), but I waited about two hours before I ate breakfast because that's what I'm used to. After getting my day started, I wasn't feeling hungry anymore so it wasn't a big deal to wait to eat breakfast. I typically wake up, I lift for about 30 minutes, some days I take a walk for 1-2 miles, then shower and eat breakfast. I don't normally feel hungry until a couple hours after waking up.

Aside from waking up hungry, yesterday and today I have had almost no appetite. Because I lift, I feel like I should be getting a good amount of protein in my diet. Typically I would be eating 25-35g of protein per meal. I had a packet of salmon and some green beans for lunch today, and I basically forced myself to finish so I could get the protein I feel like my body needs. While I'm not trying to make any hardcore gains during the 30 Day Reset, I don't want to lose any muscle mass while I go through this. It just seems like yesterday and today, after I take a few bites of my meal, I'm no longer hungry.

So, my questions: Is this loss of appetite normal or should I be concerned that I'm not eating enough? For the past three days, I've been eating 850 - 1,100 calories. Should I eat more even if I have to force myself because I'm not hungry?

Thank you!

DIM Supplement Causing Sudden Decrease in HDL

Susan writes:

Hi Robb and Nicki,

Longtime listener... maybe since 2009 ~~ Paleo Solution w' Robb and Greg. Good stuff.

As a spry 20 year old in about 2000, I started the Atkin's diet and transitioned to clean eating around 2008. My total cholesterol has always been ~200 and split 50/50 - HDL/ LDL. I've had it tested dozens of times over the years.

I've been the same weight since my teen years immediately went back to that weight post pregnancy.

My body fat by hydrostatic testing has ranged from 17% - 21% throughout my adult life, with it being more near 17% in my later adult life (more self control about calories I think).

I lift weights with intensity 6-7 days per week and keep my calories between 1600-1900 per day.

Daily Supplements:

Magnesium

Vitamin D

Cheap little multi

Fish Oil

DIM

I am now 44.

I just got my fasting bloodwork done, and my HDL has dropped from 100-110 to 77.

My LDL has gone from 100 to 149.

Two things have changed in my lifestyle:

The addition of the DIM supplement last summer. Before taking DIM, I had horrible perimenopause symptoms. I was waking up in the middle of the night so drenched in sweat that I would need to take a shower. If I wasn't drenched, I was nervous, stressing, mind-spinning and not sleeping. 100% of my symptoms are gone since starting 300mg of DIM before bed.

Simply in an effort to keep calories under control, I've entirely cut nuts out of my diet (I used to eat tons), and I eat a lot less red meat than I used to. I also have started to sometimes eat fake foods, like protein bars, which I never would have previously touched.

I've been feeling pretty good, crushing it at the gym, staying lean and mentally pretty clear. So, I was excited to get my bloodwork back. Low-and-behold my LDL is up and HDL is way down. It hasn't been below 100 in the last 20 years. So, I consider this a sudden drop.

Also, my kidney function is looking pretty mediocre. eGFR = 81 (sodium and potassium are off too)

In any case, my family tends to drop dead like flies at a pretty early age due to cardiovascular disease (skinny little Irish smokers). So, this sudden fluctuation in cholesterol is pretty scary to me.

Dr. Google says that taking progestins may cause HDL to drop.

Dr. Google also says that DIM causes an increase in progesterone.

My question is....

Do you theorize a tie between the DIM supplement and my sudden drop in precious HDL?

As a very active person with a 90% clean diet, should I care?

The other 10% is protein bars and Chardonnay.

There is very little to be said about the long term affects of DIM out there on the interwebs. So, I'm interested to hear your thoughts on it.

Thanks!

Susan

Vasectomy Research

Trevor writes:

Hello, my question harkens back to THRR episode 063. A question was asked about getting a vasectomy. Robb, you referenced someone you know who found research that indicated negative hormonal consequences (less testosterone) following vasectomy. I find myself in the same situation now as a 44 year old over-fat dude considering vasectomy for birth control. My wife has used hormonal birth control methods during our marriage. Now her functional medicine Doctor is encouraging her to cease her hormonal intervention to work on some health concerns. Before I run my business into a scalpel, I'd like to know the potential hormonal risks I'm facing.

I've done my amateur keyword searches on jama.org and pubmed, but I can't seem to find the research you mentioned in that episode. The conventional health articles say lower testosterone is not a risk. Can you help me find the research you mentioned? Or some tips on "how to fish" and do better research on my own?

Thanks for all you two do!

Trevor

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