Apulin Signaling in Older Mice

In one of our proteomics analyses, we discovered that there's a protein called Apulin that circulates in your blood and people when they're middle-aged, if they have more Apulin in their blood than other people their age. So the more Apulin you had, that just seemed to correlate with better and better outcomes. And so based on that, we tested out whether if we improved Apulin signaling in older mice, if we could improve the function of their muscle. The right preclinical experiments can be tremendously de-risking and value-creating as you move towards the clinic.