We are plunging into the pharmacology of oxycodone, a potent semi-synthetic opioid analgesic widely used in perioperative and chronic pain settings. We explore oxycodone's mechanism of action, pharmacokinetics, and pharmacodynamics
We dissect its action on mu-opioid receptors, compare it to morphine and other opioids, and review evidence regarding oral vs intravenous formulations, metabolism via CYP450 enzymes + implications for renal and hepatic impairment.
It's lost is license for prolonged release versions in acute pain!
Show notes at: https://gasgasgas.uk/oxycodone-frca-primary/
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Disclaimer / Sage Advice
> All content is educational in nature and never intended to be acted upon.
> This information is not a suitable substitute for medical advice.
> Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed.
> Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present.
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Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive
Sassy Jazzy - La Faena - Free music archive
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