If we're going to affect a neurotransmitter, we want to look at the entire cycle of that transmitter. You've got to factor in the body's ability to acetylate the choline so that you have enough acetyl group. And then there are rate limiting cofactors, like for that one, it happens to be B5,. But then the acetylcholine getting across the synapse, you have enzymes that are breaking it down - just like dopamine or serotonin.