TWiV 1133: Gain of function makes us safer
This Week in Virology
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Evolutionary Potential of Viruses and Impact on Antibody Design
The chapter explores how viruses like lentiviruses and measles can evolve to evade antibodies while maintaining cell entry, highlighting the importance of understanding antigenic variation. It discusses the implications of escape mutations on antibody resistance and the predictive nature of deep mutational scanning for designing vaccines and antibodies. The chapter also addresses the challenges in balancing science, politics, and law during the COVID-19 pandemic, emphasizing the importance of trust, adaptability, and expertise in decision-making processes.
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