Transytosis

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The term transytosis comes up a lot in the literature, which essentially just means the movement of these APOB containing lipoproteins from the plasma like in the lumen of the artery through the endothelial cells or between them into the intima. The million dollar question is why do some get ingested by macrophages and others do not? That can occur with perfectly healthy endothelium for that particle to pass right through it. Most of the disease early on is in the wall of the artery,. It's not obstructing the arterial wall movement at all. Even people who have subtle elevations of C-reactive protein (CRP) are more likely to develop diabetes

Episode #251. Cardiovascular disease is one of the biggest killers in the Western world, and it’s vital that we understand cardiovascular health in order to improve lifespan and healthspan. In this episode, I sit down with Dr Thomas Dayspring for Part One of a three-part deep dive into cardiovascular disease and blood lipids. In this introductory episode, we examine how our body absorbs lipids and transports them throughout the body – and what happens when it goes wrong.

Specifically, we discuss:

Intro (00:00)
Turning a family heartache into a mission (05:12)
Atherosclerosis and the role of lipids (14:52)
Lipoproteins & cholesterol transport and recycling (28:01)
Cholesterol's role in lipoproteins (54:00)
Is ApoB a more accurate marker of cardiovascular risk? (58:38)
Endothelial transcytosis of lipoproteins (1:07:10)
LDL aggregation (1:16:42)
LDL particle retention and inflammation (1:23:15)
Difference between veins and arteries (1:28:55)
Atherosclerosis and genetics (1:30:22)
High-fat diets and cholesterol (1:44:01)
Fiber and cholesterol absorption (1:48:14)
Outro (1:57:48)

The best place to connect with Dr Thomas Dayspring is on Twitter, @DrLipid. Learn more about Dr Dayspring’s career and current work on LinkedIn.

Discover more insights and supporting studies in the full show notes.

To assist with the digestibility of this content, Dr Dayspring, my team, and I have included extensive illustrations and graphs to the video format of these episodes. If you are visually inclined, you can watch these episodes on The Proof YouTube channel. Even if you prefer listening through audio the first time, I highly recommend coming back for a second pass with the video versions. These episodes are investments into a healthier future.

Get your copy of the Lipid Series Cheat Sheet at theproof.com/lipidseries. This comprehensive resource provides valuable insights on assessing your risk, preventing, and treating atherosclerotic cardiovascular disease (ASCVD), the leading cause of death worldwide. The PDF not only highlights key learnings from the 3-Part Lipid Series but also includes a 1-week meal plan designed to promote healthy cholesterol levels.

Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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