For some people just the idea of experience something you haven't experienced before has a beneficial effect on the experience of being alive. I think that this is a highly gendered decision and in the context of contemporary western society where at least women now tend to have the choice right. If we do make this discovery then we have to give up significant things that we value but it's not so easy to choose the path of epistemic revelation because you don't quite know what you're getting or giving up.
Philosopher and author L.A. Paul talks about her book Transformative Experience with EconTalk host Russ Roberts. Paul explores the uncertainties that surround the transformative experiences that we choose and that happen to us without choosing. How should we think about the morality and personal impact of these kinds of experiences, especially when some decisions are very hard or impossible to reverse? Examples include becoming a vampire, having children, religion, and other life experiences and choices.