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#45 Biostats & Clinical Trial Design, with Frank Harrell

Learning Bayesian Statistics

CHAPTER

Controlling Alpha in a Longitudinal Study

There's this real preoccupation in the classic a frequentis designed world to control the type one operating characteristic, a probability alpha. The idea that you have to control the probability of ever making an assertion of efficacy if the treatment does nothing has made every trial much slower in getting off the ground. A base cuts through that, because bays says, we want to maximaze the probability of making the right decision once the data are available.

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