Translating Aging cover image

Eliminating Senescent Cells by Activating the Immune System (Robin Mansukhani, Deciduous Therapeutics)

Translating Aging

00:00

The Effects of Alpha-Galactosel Ceramide on IMKT Cells

There was a nice paper from the laboratory of your coworker and Neil Buchon that used a certain class of lipid molecule, alpha-galactosel ceramide, to activate IMKT cells in mice. Can you tell us a little bit about that story? Yeah. We see with a single dose in the animals, we can get the NKT cell population active and proliferating within about four days. And also by day four to day five, you see a dramatic reduction in senescent cells in the tissue of interest. Now we can, so basically we would induce disease over the course of about four months in the case of the high-fat type to diabetes mice. After four months

Transcript
Play full episode

The AI-powered Podcast Player

Save insights by tapping your headphones, chat with episodes, discover the best highlights - and more!
App store bannerPlay store banner
Get the app