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Ep. 72: “IMMUNOLOGY2024™: Innovations in Immunology” Featuring Dr. Akiko Iwasaki, Francisco Gomez-Rivera, and Dr. Jason Augustine

The Immunology Podcast

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Protein Complex and Autoimmunity in Mice

This chapter explores the role of a protein complex in silencing the second X chromosome in female organisms and its potential effects on immunity. The researchers introduce a non-silencing version of the complex in male mice and study the autoimmune responses observed, including the development of a lupus model. They also discuss the relevance of this study to humans with systemic lupus erythematosus (SLE) and briefly mention the genetic aspect and potential consequences of losing the Y chromosome.

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