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The isomers of sisomers are structurally very similar to mitriginen, yet a little bit different. And even that small difference may have an impact on how they act on the adronugic system or the serotronurgic system. So fom we basically now go back from these surv s and from some human observations,. We try to to look at e animal data and in vitro celline data to actually find the active components and the mechanisms by which these effects that humans report are actually elicited.