Managing Coagulation Disorders and Factor Replacement Therapy

This chapter delves into the management of coagulation disorders through factor replacement therapy and prothrombin complex concentrates. Discussions include dosing strategies, indications for three and four-factor PCC, and considerations for thrombotic risks. Specific cases highlight the use of activated PCC in conditions like hemophilia A with inhibitors and the initiation of massive transfusion protocols in critical patients with extensive injuries and complications.