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Key updates on CAR-T therapy for ALL

VJHemOnc Podcast

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Exploring Approaches to Reduce Neurotoxicity in CAR-T Therapy for ALL

This chapter explores different strategies to improve CAR-T therapy for ALL, including manipulation of CAR construct, cytokine pathways, and disease burden. It discusses the role of disease burden in neurotoxicity and highlights the potential benefits of debulking or bridging therapy. The chapter also mentions a recent study with high response rates and no CRS or neurotoxicity.

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