#250 Nephrotic Syndrome vs. Glomerulonephritis with Kidney Boy, Dr. Joel Topf
The Curbsiders Internal Medicine Podcast
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The Under-Fill Hypothesis of the Phroetic Syndrome
The current probably dominant hypothesis, especially among adult nephrologists, is called the overfill hypothesis. The idea is that there's a primary increase in sodium retention as part of your nephrotic syndrome. That when the kidney is diseased, it's gonna increase its sodium retention. And anytime you get volume overloaded, you'll get that'll lead to edema. There's a number of different experimental evidence to support that. Not only we've got the mechanism for sodium retention down, one of the really strong pieces of data is the treatment of minimal change disease.
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