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Self Experiments In the Biochemically Unoptimized State

Mastering Nutrition

CHAPTER

The Paradox of Lactate in the Fasting and Postprandial States

The deficiency of the biotin-dependent enzyme pyruvate carboxylase causes a paradoxical rise in fasting lactate and a paradoxical postprandial suppression of lactate. Why? Because pyruvates needed to make oxaloacetate, which is converted to aspartate with the help of vitamin B6. Aspartate is needed for the malate aspartate shuttle, which transports electrons from NADH in the cytosol to NADH inthe mitochondrion. If you live in a city, you might think of this as a shuttle line that's connecting two larger buses or train lines.

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