TWiV 1189: Viruses making waves
This Week in Virology
00:00
Unmasking NSP4: Insights into Rotavirus Pathogenesis
This chapter explores the critical role of the viral non-structural protein NSP4 in rotavirus pathogenesis and its impact on gastroenteritis, particularly in children. Through a detailed examination of NSP4's function as a viroporin and its involvement in calcium signaling, the discussion highlights implications for vaccine development and the challenges faced in creating effective vaccines. The chapter also reflects on the broader effects of rotavirus gastroenteritis and the dynamics of acute symptoms felt globally.
Transcript
Play full episode
