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3min chapter
There’s a thousand genes for that! (Ep 98)
Big Biology
The Implications of Loci of Small Effects on Pluritropy
There's only you know 20 or 25,000 genes say in an average mammal. That implies that almost all of these loci are going to have some sort of pleiotropic effect on more than one trait so does it mean that the genome is kind of a giant tangled of pleiotropy? I think you wonder how it works at all because it's such a contrast from the sort of biochemistry textbook and we don't even know theoretically whether gene regulation really is as simple as these halfway diagrams. We tend to miss out on a lot of very diffuse function which is really important in aggregate and yet which is hard to observe.
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