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Episode #199: November 2022 Research Review
Barbell Medicine Podcast
Psilocybin Therapy for Treatment Resistant Major Depression
Psilocybin is a serotonergic psychedelic drug derived from mushrooms. It causes an increase in serotonin to be released from various serotonin releasing nerves. The proposed mechanism based on functional MRI data of psilocybin basically shows decreased blood flow to the amygdala, that's a small area of the brain involved in memories and emotions. This can cause underlying maladaptive thoughts of guilt and ruminations about ones inadequacy.
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