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Ep. 97: “Viral Structures” Featuring Dr. Erica Saphire

The Immunology Podcast

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Deciphering Immune Dynamics in Cancer and Infections

This chapter explores the role of IL-33 activated ILC2s in the formation of tertiary lymphoid structures within pancreatic cancer and their surprising connections to gut health and immune responses. It also highlights the dynamics of T-cell exhaustion, detailing the emergence of TPEX precursors and their crucial role in maintaining immunity during chronic infections and cancer treatments. By examining immune responses to acute versus chronic infections, the chapter challenges traditional views on T cell behavior and the significance of antigen persistence.

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