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Loneliness
A 2009 UC Berkeley study found that good relationships can add a decade to your lifespan, potentially a decade. Good relationships are second only to genetics in terms of predicting both health and longevity in humans. Loneliness before the 19th century basically didn't exist because we were so enmeshed in societies. It wasn't until literally Frankenstein that you heard lonely start to be used as a negative thing.