I think avoidance of HRT over the last 20 years has definitely affected women's health. We are seeing earlier osteoporosis, bone loss and vaginal dryness. I've seen women in their late 50s, early 60s having vertebral fractures. The long-term effects in terms of health, we can't be certain yet, but also effects on vaginal dryness, sexual function and relationships. So it's been horrible.

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