The Different Views of Standing Genetic Variation

What is mutation bias? How does it affect evolution?

In this episode, we talk with Arlin Stoltzfus, a research fellow at the University of Maryland’s Institute for Bioscience and Biotechnology Research. Arlin studies mutation bias – the idea that some types of mutations occur more often than others – and how these patterns can influence the evolutionary trajectories of populations. In the chat, we contrast this mutation-centric approach to evolution with more standard views in which selection does most of the creative heavy lifting. We center the talk around Arlin’s 2021 book - Mutation, Randomness, and Evolution, which offers a new conception of variation as a difference-maker in evolution. Looking forward, Arlin argues that a better understanding of mutation will make it easier to predict the origins and outcomes of different cancers and the evolution of infectious diseases and crop pests.

Cover art by Keating Shahmehri