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Is there a real "truth serum"?

Stuff They Don't Want You To Know

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Psychedelics as a Truth Serum

The concept of even using psychedelic substances as a truth serum is odd. The barbitits by disrupting defensive patterns may sometimes be helpful in interrogation, but even under the best conditions, they will elicit an output contaminated by deception and fantasy. There's this whole thing about someone under interrogation who is just boring people to tears because they're talking about everything except like they're giving you all the information that happens in their heads. A recent example of this is from the ant man films.

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