This chapter explores the journey of a former pastor turned researcher in the field of psychedelic medicine, focusing on the antidepressant effects of ketamine and its potential in combination with cognitive behavioral therapy for depression. It highlights the paradigm shift in psychiatry with the rapid and lasting effects of ketamine compared to traditional antidepressants, while emphasizing the importance of safe and controlled ketamine therapy. The chapter also delves into the historical development of ketamine, from its origins in anesthesia to its current status as an essential medicine for various uses.