Alk Inhibitor

There is actually a planned study of adding in amirhantimab to alk inhibitor that I think Justin's going to be part of that studies and Tages Petilla's leading that one. We've really been fortunate in the field to now have you know three generations of alk inhibitors with approved agents and has been alluded to a fourth generation currently in clinical trials. So against alk you see increased CNS penetration but then you see increased coverage of alk point resistance mutations so that's how I generally think about these agents.