HLA-E-restricted immune response in EBV infection, the role of NRX-0492 in CLL, and NSAIDs for bone marrow failure in Ghosal Hematodiaphyseal Dysplasia
Blood Podcast
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Non-Steroidal Anti-Inflammatory Drugs as a Targeted Therapy for Bone Marrow Failure in Gosal-Himato-Dia Physial Displasia
Portilinha notes that this is unexpected because a non-covalent inhibitor is used as the hook and T474 residue impairs access to the BTK binding pocket. She concludes that future clinical studies will be needed to determine if BTK degraders have improved clinical activity and fewer side effects compared to regular kinase inhibitors.
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