Genetics and Panic: The COMT Variant

Fear is one of the earliest emotions to have evolved. Most vertebrates – and possibly some invertebrates – show fear when they are threatened. At its most core, fear keeps us alive, helping us flee from predators or avoid dangerous environments. But why does this process sometimes backfire, leaving us paralysed by otherwise harmless phobias? And why do so many people deliberately seek out fearful situations, from horror movies to parachute jumps, when instinct tells us to do the opposite? Can understanding the biology of fear help us conquer it, or simply make us more vulnerable to its impact?

This lecture was recorded by Robin May on the 1st of October 2025 at Bernards Inn Hall, London

Professor of Infectious Disease at the University of Birmingham, and (interim) Chief Scientist at the UK Health Security Agency, Robin May was appointed Gresham Professor of Physic in May 2022. Between July 2020 and September 2025 he served as Chief Scientific Adviser at the Food Standards Agency (FSA). 

Professor May’s early training was in Plant Sciences at the University of Oxford, followed by a PhD on mammalian cell biology at University College London and the University of Birmingham. After postdoctoral research on gene silencing at the Hubrecht Laboratory, The Netherlands, he returned to the UK in 2005 to establish a research program on human infectious diseases. He was Director of the Institute of Microbiology and Infection at the University of Birmingham from 2017-2020. 

Professor May continues his work on Infectious Disease at the University of Birmingham. A Fellow of the Academy of Medical Sciences, Wolfson Royal Society Research Merit Fellow and Fellow of the American Academy of Microbiology, Professor May specialises in research into human infectious diseases, with a particular focus on how pathogens survive and replicate within host organisms.

As the FSA’s Chief Scientific Adviser, Professor May provides expert scientific advice to the UK government and plays a critical role in helping to understand how scientific developments will shape the work of the FSA, as well as the strategic implications of any possible changes.

The transcript of the lecture is available from the Gresham College website: https://www.gresham.ac.uk/watch-now/why-fear

Gresham College has offered free public lectures for over 400 years, thanks to the generosity of our supporters. There are currently over 2,500 lectures free to access. We believe that everyone should have the opportunity to learn from some of the greatest minds. To support Gresham College's mission, please consider making a donation: https://www.gresham.ac.uk/get-involved/support-us/make-donation/donate-today

Website:  https://gresham.ac.uk

X: https://x.com/GreshamCollege

Facebook: https://facebook.com/greshamcollege

Instagram: https://instagram.com/greshamcollege

Bluesky: https://bsky.app/profile/greshamcollege.bsky.social 

TikTok: https://www.tiktok.com/@greshamcollege

Support Us: https://www.gresham.ac.uk/get-involved/support-us/make-donation/donate-today

Support the show