June 2023 Neurology Recall: Biomarker Discovery in Parkinson Disease
Neurology® Podcast
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The Role of Protein Apathy in Neurodegenerative Diseases
Terrific and Lucilla, we have lots of different protein apathy in neurology neurodegenerative diseases associated with alpha-synuclein or amyloid or tau. So when you say you're exploiting the pre-unlike characteristics of these proteins you mean the ability of the protein to misfold and actually induce that same misfolding in the other protein is that accurate? Yeah in the chapter of prion diseases such as the chroidsphal jack of disease prion protein undergoes a conformational transformation that leads to aggregation this is the first part of the story. This aggregated structure further promotes the conversion of other prion proteins into pathological conformation in this
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