The Immunology Podcast cover image

Ep. 12: “The Power of Cell Therapy” Featuring Dr. Jeffrey Bluestone

The Immunology Podcast

00:00

Exploring Neutrophil Ferroptosis and Mitochondria in Lupus Pathogenesis

This chapter delves into the mechanisms of autoimmunity in lupus, focusing on the role of ferroptosis in neutrophil cell death and its connection to disease manifestations. It discusses the impact of glutathione peroxidase-4 suppression on lipid-reactive oxygen species production and neutrophil killing, shedding light on potential therapeutic interventions. The chapter also examines the presence of residual mitochondria in red blood cells of lupus patients and its contribution to inflammation and interferon production, as well as the implications of TCF1 deficiency in Treg cells on T cell proliferation and colon cancer severity.

Transcript
Play full episode

The AI-powered Podcast Player

Save insights by tapping your headphones, chat with episodes, discover the best highlights - and more!
App store bannerPlay store banner
Get the app