The Twin Cycle Model for Type Two Diabetes

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In the U.S., about one third of adults are obese, and almost 75% overweight or obese. This puts people at a higher risk of developing type two diabetes and non-alcoholic fatty liver disease. Jeff Gordon: How do you think the microbiome could be involved in the people gaining weight? He says there hasn't been much research on this beyond those initial studies on the energy harvesting capacity of the microbiome.

Episode #267. Join me for a deep dive into the influence of the gut microbiome on inflammation and metabolic disease. In this fascinating exchange with Dr Suzanne Devkota, we explore the role of the gut in these conditions, shedding light on food allergies, IBD, and obesity. You’ll learn the practical tips you need to nurture a healthy microbiome, as well as gain a better understanding of what we do – and don’t – know about this incredible system.

Specifically, we discuss:

Intro (00:00)
The evolving field of microbiome research (02:13)
Gut microbe on social media (09:32)
Microbiome definition (12:48)
Why the focus on gut bacteria? (13:55)
Differences in Microbes (16:02)
Microbial shifts and adaptations (18:45)
Microbes perturbations (21:35)
Human microbiome in evolution (23:54)
Healthy microbiome and diversity (27:47)
Is the microbiome the sole driver of metabolic diseases? (33:05)
Dietary patterns and FODMAP intolerance (41:07)
Saturated fat and gut health (49:15)
Microbiome metabolites and heart disease risk (57:42)
Inflammatory bowel disease (IBD) and dysbiosis (1:02:09)
Food additives (1:12:29)
Supporting the microbiome in IBD (1:15:29)
Microbiome's interaction with fat cells (1:16:52)
Short-chain fatty acids and appetite regulation (1:29:26)
Practical tips for nourishing a healthy gut (1:31:05)
Microbiome's interaction with Polyphenols (1:38:43)
On supplements and fermented foods (1:39:15)
Factors affecting gut health beyond nutrition (1:46:22)
Outro (1:50:10)

Connect with Dr Suzanne Devkota on Instagram and Twitter. Learn more about her research at http://www.devkotalab.com/thelab.

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Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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