
36 | Laurence Hurst and the slime mold model of discovery
Night Science
00:00
How to Make a Good Transgene for Gene Therapy
We discovered that by doing some gfp experiments and if you make gFP which is gc rich at the third sites just by modifying the third site it expresses very very well indeed in the mammalian cell line. The same thing if it's a t-rich at the third site there's nothing, so we've got a lovely little quality control to get out of the nucleus. We have one specialist export channel which basically says know your mind straight through and another which says you look as seriously dodgy as anything i'm going to really check out your passport and if it doesn't work you're not going to go out. It turns out that the 80 rich versions of g FP were being
Transcript
Play full episode