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Speral Actin and Cirrhosis
Dr. Paddellino has seen patients that have this refractory hyperkalemia and acidosis many in the hospital and they're still we're still pushing it It's a word of caution too You have to as good as it is. There's a very long acting I cannot think of any other direct perhaps metolo zone is also a very longacting one. Those are the two Yeah, but that's 24 even 48 hours, but I think you're yeah.
The Channelers went where no nephrology podcasters have gone before, recording in front of a live audience at the National Kidney Foundation Clinical Meeting in Austin. We had all eight Channelers doing a live podcast.
We did a Freely Filtered-inspired draft of the best diuretics.
The draft order:
Leticia Rolon
Anna Gaddy
Joel Topf
Roger Rodby
Josh Waitzman
Amy Yau
JC Velez
And Melanie Hoenig
References
JC
Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease
Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia
Josh
Review on amiloride development https://pubmed.ncbi.nlm.nih.gov/7039345/
Toad bladder: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351665/
Amiloride derivatives that inhibit flagella: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544414/
Amiloride as taste sensor: https://www.science.org/doi/10.1126/science.6691151
Amiloride + ddavp for DI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518801/
Amy
Acetazolamide reversibly inhibits water conduction by aquaporin-4
Inhibition of Human Aquaporin-1 Water Channel Activity by Carbonic Anhydrase Inhibitors
Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus
Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus
In Vivo Antibacterial Activity of Acetazolamide
Roger
50th anniversary of aldosterone
Joel
Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure
Empagliflozin and Heart failure: Diuretic and Cardiorenal Effects
Anna
Clinical Results of Treatment of Diabetes Insipidus with Drugs of the Chlorothiazide Series
Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride
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