The Positive Feedback Loop That Causes Atherosclerosis

There's a level at which just too much cholesterol overwhelms your macrophage. The more oxidized LDL you have, the more likely it is the macrophages are going to become totally overwhelmed by the cholesterol that's in the environment without having an overall high level of cholesterol. Your plaques are a macrophage graveyard. And that is the underlying problem that causes atherosclerosis. But frankly, it doesn't work enough. We've demonstrated we, the research community, have demonstrated that if you really, really aggressively lower LDL cholesterol to 10% of human normal, you're still not going to stop people dying.

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