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Audio long read: She was convicted of killing her four children. Could a gene mutation set her free?

Nature Podcast

CHAPTER

Defining Calmodulin Mutations

Three calmodulin genes are very rare in population databases of all the highly conserved genes in evolution. declaring a variant pathogenic now requires a fairly high bar of proof, says Watkins. In large population databases, a small number of seemingly healthy people have calmodulin mutations - albeit in different locations to known pathogenic variants. It is possible for Folbig to live with a pathogenic mutation, while her daughters might have died from it.

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