John Nash the Nobel Laureate economics when he was in the worst of his delusions and challenges mentally. They limited their damage to him to incarceration physical constraints and other thing but not chakra. The most famous person to have been lobotomized was John F Kennedy's sister who was somewhat mildly brain damaged during birth as my understanding she had some mild cognitive disability.
When physician Walter Freeman died in 1972, he still believed that lobotomies were the best treatment for mental illness. A pioneer in the method, he was a deeply confident and charismatic man who eagerly spread the technique in America, long after the rise of alternative treatments that were less destructive. Listen as journalist Megan McArdle and EconTalk's Russ Roberts discuss what McArdle calls the "Oedipus Trap": mistakes that no one can live with, even if they were innocently made, and how admitting such mistakes to ourselves is nearly impossible. They also discuss the complexity of the credo, "follow the science."